Medical Research (H99) 990 on File

HUMAN PROTEOME ORGANIZATION HUPO

EIN: 80-0814948 · NEWTON, MA 02461-1229 · United States · FY 2024 Data

3 out of 5 53 / 100 Based on 2+ years of filings

Financial strength (30%) 79/100

Reliability (20%) 50/100

Effectiveness (25%) 78/100

Impact (25%) No data yet

Financial data: FY 2024 · Scored 9/13/2026

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CharityAI™ Score

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Financial Overview — FY 2024

$233K

Total Revenue

$299K

Total Expenses

$912K

Net Assets

Employees

Revenue Sources

Expense Breakdown

Program Expense Ratio 77.2%

Fundraising Efficiency N/A

Operating Reserve 36.68x

Liability-to-Asset 14.1%

Revenue Diversification 95.9%

Executive Compensation $0

Compared with Peers

FY 2024

Compared with 726 similar organizations (United States, Medical Research, $100K–$1M in expenses), FY 2024.

This organization Middle half of peers (P25–P75) Peer median

Ratio	This org	Peer median	Position (P10 → P90)
Program expense ratio Program expenses / total expenses · higher is better	77.2%	84.5%	P10P90	Below median
Admin expense ratio Management and general / total expenses · lower is better	22.8%	11.4%	P10P90	Bottom quarter
Fundraising expense ratio Fundraising expenses / total expenses · lower is better	0.0%	0.0%	P10P90	Top quarter
Operating reserve Months of expenses covered by net assets · higher is better	36.7 mo	13.4 mo	P10P90	Top quarter
Liabilities to assets Total liabilities / total assets · lower is better	14.1%	0.4%	P10P90	Bottom quarter
Revenue concentration Share of revenue from the largest source · lower is better	95.9%	93.3%	P10P90	Below median
Revenue growth Year over year revenue growth	-84.9%	9.1%	P10P90
Expense growth Year over year expense growth	-77.7%	8.8%	P10P90
Surplus margin Surplus as a share of revenue	-28.1%	1.8%	P10P90

Financial History

Year	Revenue	Expenses	Net Assets	Program %
2024	$233K	$299K	$912K	77.2%
2023	$1.5M	$1.3M	$978K	94.0%
2022	$1.1M	$900K	$771K	93.7%
2021	$537K	$491K	N/A	—

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Organization Details

EIN: 80-0814948
State: MA
City: NEWTON
ZIP: 02461-1229
Classification: H99
Category: Medical Research
Rating: 3★
Coverage: A
Last Updated: Aug 2026
Form 990: On File

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CharityAI™ rates charities from 0 to 100 using public filings (IRS Form 990 and the equivalent registries outside the US) together with the information the charity itself provides on DonationX. Ratings are recalculated every quarter, without human bias, and shown as stars.

Four pillars

Financial strength30%

Program expense ratio, fundraising efficiency, operating reserves, liabilities and revenue diversification, compared with similar organizations.

Reliability20%

Standing with the registry, filing history, verification and how complete the profile is.

Effectiveness25%

How much goes to programs and how consistently the organization delivers them.

Impact25%

The outcomes the charity reports on DonationX: people served, cost per service and results.

Stars

★★★★★ 80–100 ★★★★☆ 60–79 ★★★☆☆ 40–59 ★★☆☆☆ 20–39 ★☆☆☆☆ 1–19

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